文章基本信息

标题：Factors associated with prolonged duration of viral clearance in non-severe SARS-CoV-2 patients in Osaka, Japan
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作者：Emma Nakagawa Hoffman ; Haruna Kawachi ; Atsushi Hirayama 等
期刊名称：Environmental Health and Preventive Medicine
印刷版ISSN：1342-078X
电子版ISSN：1347-4715
出版年度：2021
卷号：26
DOI：10.1186/s12199-021-01035-y
语种：English
出版社：Springer Japan
摘要：We investigated factors associated with prolonged viral clearance of SARS-CoV-2 among non-severe adult patients in Osaka, Japan. A total of 706 laboratory-confirmed COVID-19 patients were enrolled in this longitudinal observational study between 29 January 2020 and 31 May 2020, across 62 hospitals and three non-hospital recuperation facilities. Methods Logistic regression analysis was performed to investigate the factors associated with prolonged (29 days: upper 25% in duration) viral clearance of SARS-CoV-2. Linear regression analysis was conducted to assess these factors 14 days after symptom onset. Results The median duration of viral clearance was 22 days from symptom onset. After adjustment for sex, age, symptoms, comorbidity, and location of recuperation, comorbidities were associated with prolonged duration: (OR, 1.77 [95% CI, 1.11–2.82
关键词：COVID-19; Virus shedding; Comorbidity; Longitudinal studies