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标题：The Effects of Omega-3 and Melatonin Supplementation Associated with Moderate Physical Exercise on Biochemical Parameters, Hippocampus Morphometry, and Memory in Wistar Rats
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作者：Danielle Dutra Pereira ; Danielle Dutra Pereira ; Wanessa Noadya Ketruy de Oliveira 等
期刊名称：Journal of exercise physiology online
印刷版ISSN：1097-9751
出版年度：2019
卷号：22
期号：5
页码：200-219
语种：English
出版社：American Society of Exercise Physiologists
摘要：Pereira DD, Oliveira WNK, Fialho GV, Lima WSA, Siva JESS, Elias LS, Aguiar LA, Almeida THS, de Souza RF, Evêncio-Neto J. The Effects of Omega-3 and Melatonin Supplementation Associated with Moderate Physical Exercise on Biochemical Parameters, Hippocampus Morphometry, and Memory in Wistar Rats. JEPonline 2019;22(5):200-219. The purpose of this study was to evaluate the effects of omega-3 and melatonin supplementation associated with moderate exercise. Sixty-day-old rats were divided into 8 Experimental Groups (n = 5 animals per group) according to the treatment: (1) A, omega-3; (2) B, melatonin; (3) C, physical exercise; (4) D, omega-3 and melatonin; (5) E, omega-3 and exercise; (6) F, melatonin and exercise; (7) G, omega-3, melatonin, and exercise; and (8) H, Control. The body mass at 30 days postnatal (M30) of the animals in BGroup (42.47 ± 1.23) was lower compared to all Groups. At 60 days postnatal (M60), A(198.4 ± 4.15), B (213.3 ± 3.63), and C Groups (208.8 ± 6.11) presented higher body weightthan the F Group (161.5 ± 6.37) and the H group (151.8 ± 4.80). The G group (172.4 ± 6.42)had a lower mean body weight than the B Group. At 30 days of age, VLDL (79.08 ± 12.89)and triglyceride (395.4 ± 64.43) in the F Group were higher than the B Group (30.44 ± 3.34and 152.2 ± 16.9 respectively). After 60 days, the HDL levels of the F Group (77.13 ± 13.32)had increased higher than the D Group (25.98 ± 2.51). Regarding the glycemic response, theD Group (248.2 ± 24.48) was higher than all the Groups, while the H Group (155.6 ± 16.80)differed from the A, C, and F Groups. Regarding hippocampal morphometry at M30, only theD Group differed from the A and G Groups, presenting a higher neuronal density. At M60, theB Group presented a higher number of neurons than the A, C, E, F, and H Groups. The Cgroup demonstrated neuronal reduction in relation to the A, D, E, F, and G Groups. When Dwas observed, it demonstrated a greater number of neurons than the A, E, F, and H Groups.Finally, the H Group had lower neuronal density when compared to the A, E, F, and GGroups. For the recognition test, there were no differences between the evaluated treatmentsat 30 and 60 days of age. Physical exercise related to omega-3 and melatoninsupplementation after 30 and 60 days resulted in changes in body weight, biochemicalparameters, and hippocampus morphometry, but did not interfere with the memory of WistarRats.
关键词：Exercise;Hippocampus;Melatonin;Memory;Omega-3