文章基本信息

标题：Multi-level decoding of task sets in neurophysiological data during cognitive flexibility
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作者：Vanessa Petruo ; Adam Takacs ; Moritz Mückschel 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：12
页码：1-22
DOI：10.1016/j.isci.2021.103502
语种：English
出版社：Elsevier
摘要：SummaryCognitive flexibility is essential to achieve higher level goals. Cognitive theories assume that the activation/deactivation of goals and task rules is central to understand cognitive flexibility. However, how this activation/deactivation dynamic is implemented on a neurophysiological level is unclear. Using EEG-based multivariate pattern analysis (MVPA) methods, we show that activation of relevant information occurs parallel in time at multiple levels in the neurophysiological signal containing aspects of stimulus-related processing, response selection, and motor response execution, and relates to different brain regions. The intensity with which task sets are activated and processed dynamically decreases and increases. The temporal stability of these activations could, however, hardly explain behavioral performance. Instead, task set deactivation processes associated with left orbitofrontal regions and inferior parietal regions selectively acting on motor response task sets are relevant. The study shows how propositions from cognitive theories stressing the importance task set activation/deactivation during cognitive flexibility are implemented on a neurophysiological level.Graphical abstractDisplay OmittedHighlights•Stimulus-related, motor, and response selection aspects of task set were decoded•Activation of task rule information occurs at multiple neurophysiological levels•Activation and deactivation of rule sets contributes to cognitive flexibilityBiological sciences; Neuroscience; Behavioral neuroscience; Cognitive neuroscience