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标题：Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial
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作者：Ryusei Uchio ; Kengo Kawasaki ; Chinatsu Okuda-Hanafusa 等
期刊名称：Nutrition Journal
印刷版ISSN：1475-2891
电子版ISSN：1475-2891
出版年度：2021
卷号：20
DOI：10.1186/s12937-021-00748-8
语种：English
出版社：BioMed Central
摘要：Background The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health. Methods We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05). Results After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index ( p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein ( p < 0.05) and complement component 3 ( p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score ( p < 0.05) and POMS anger-hostility score (p < 0.05). Conclusion CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance. Trial registration UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607 Supplementary Information The online version contains supplementary material available at 10.1186/s12937-021-00748-8.
关键词：Turmeric (Curcuma longa); Bisacurone; Body mass index (BMI); Turmeronol; Chronic inflammation; C-reactive protein (CRP); Complement component 3 (C3); 36-item short-form health survey (SF-36); Profile of mood states (POMS)