文章基本信息

标题：Direct-to-Consumer Genetic Testing in Korea: Current Status and Significance in Clinical Nutrition
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作者：Ga Young Lee ; Sung Nim Han
期刊名称：Clinical Nutrition Research
印刷版ISSN：2287-3732
出版年度：2021
卷号：10
期号：4
页码：279-291
DOI：10.7762/cnr.2021.10.4.279
语种：English
出版社：KoreaMed Synapse
摘要：Direct-to-consumer genetic testing (DTC-GT) provides a means for consumers to gain insights into their genetic background and how it relates to their health without the involvement of medical institutions. In Korea, DTC-GT was introduced in 2016 in accordance with the legislation on Paragraph (3) 2 of Article 50 of the Bioethics and Safety Act. Only 12 genetic test items involving 46 genes were approved at first, but the approved items were expanded to 70 in November 2020. However, the genetic test items of DTC-GT services in Korea are still restricted to the wellness area, and access to disease risk related information is only permitted to medical institutions. Further, studies revealing the relationship between genotype differences and responses to nutrients, food components, or nutritional status are increasing, and this association appears to be robust for some genes. This strong association between genetic variations and nutrition suggests that DTC-GT can be used as an important tool by clinical nutritionists to gain insights into an individual's genetic susceptibilities and provide guidance on nutritional counseling and meal planning based on the patient's genetic information. This review summarized the history and current status of DTC-GT and investigated the relationship between genetic variations with associated phenotypic traits to clarify further the importance of DTC-GT in the field of clinical nutrition.
关键词：enDirect-to consumer screening and testing;Genetic variation;Nutrigenomics;Nutritionists;Clinical decision-making