文章基本信息

标题：Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
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作者：Fatemeh Esfahanian ; Mojgan Mirabdolhagh Hazaveh ; Laya Hooshmand Garehbagh 等
期刊名称：Iranian Journal of Public Health
印刷版ISSN：2251-6085
电子版ISSN：2251-6093
出版年度：2021
卷号：50
期号：8
DOI：10.18502/ijph.v50i8.6817
语种：English
出版社：Tehran University of Medical Sciences
摘要：Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.
关键词：Mitochondrial DNA;Hashimoto's thyroiditis;Oxidative stress;Autoimmunity