文章基本信息

标题：Identification of cardiac afterload dynamics from data
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作者：Henry Pigot ; Jonas Hansson ; Audrius Paskevicius 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2021
卷号：54
期号：15
页码：508-513
DOI：10.1016/j.ifacol.2021.10.307
语种：English
出版社：Elsevier
摘要：AbstractThe prospect ofex vivofunctional evaluation of donor hearts is considered. Particularly, the dynamics of a synthetic cardiac afterload model are compared to those of normal physiology. A method for identification of continuous-time transfer functions from sampled data is developed and verified against results from the literature. The method relies on exact gradients and Hessians obtained through automatic differentiation. This also enables straightforward sensitivity analyses. Such analyses reveal that the 4-element Windkessel model is not practically identifiable from representative data while the 3-element model underfits the data. Direct comparison of aortic pressure–flow relations, without relying on matching of fitted Windkessel model parameters, is therefore suggested as an alternative for comparing afterload dynamics.
关键词：KeywordsMedical systemsIdentifiabilityWindkessel models