文章基本信息

标题：Reactivation of latent tuberculosis through modulation of resuscitation promoting factors by diabetes
本地全文：下载
作者：Arpana Verma ; Maninder Kaur ; Lakshya Veer Singh 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-99257-1
语种：English
出版社：Springer Nature
摘要：The evidence of an association between diabetes and latent tuberculosis infection (LTBI) remains limited and inconsistent. Thus, the study aims to delineate the role of diabetes in activation of latent tuberculosis infection. Murine model of latent tuberculosis and diabetes was developed, bacillary load and gene expression of resuscitation promoting factors ( rpfA-E) along with histopathological changes in the lungs and spleen were studied. Treatment for LTBI [Rifampicin (RIF) + Isoniazid (INH)