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标题：Hydrogen and Methane Breath Test in the Diagnosis of Lactose Intolerance
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作者：Charlotte De Geyter ; Kris Van de Maele ; Bruno Hauser 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：9
DOI：10.3390/nu13093261
语种：English
出版社：MDPI Publishing
摘要：The hydrogen (H 2) breath test is a non-invasive investigation used to diagnose lactose intolerance (LI). Patients with LI may also expire increased amounts of methane (CH 4) during a lactose test. The aim of this study is to evaluate the contribution of CH 4 measurements. We tested 209 children (1–17 years old) with symptoms suggesting LI with lactose H 2 and CH 4 breath tests. The result was positive when the H 2 excretion exceeded 20 parts per million (ppm) and the CH 4 was 10 ppm above the baseline. A clinician, blinded for the results of the breath test, registered the symptoms. Of the patient population, 101/209 (48%) were negative for both H 2 and CH 4; 96/209 (46%) had a positive H 2 breath test result; 31/96 (32%) were also positive for CH 4; 12/209 (6%) patients were only positive for CH 4. The majority of hydrogen producers showed symptoms, whereas this was only the case in half of the H 2-negative CH 4 producers. Almost all patients treated with a lactose-poor diet reported significant symptom improvement. These results indicate that CH 4 measurements may possibly be of additional value for the diagnosis of LI, since 5.7% of patients were negative for H 2 and positive for CH 4, and half of them experienced symptoms during the test.
关键词：enlactose intolerance;hydrogen breath test;methane