文章基本信息

标题：Maternal Fructose Diet-Induced Developmental Programming
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作者：Michael D. Thompson ; Brian J. DeBosch
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：9
DOI：10.3390/nu13093278
语种：English
出版社：MDPI Publishing
摘要：Developmental programming of chronic diseases by perinatal exposures/events is the basic tenet of the developmental origins hypothesis of adult disease (DOHaD). With consumption of fructose becoming more common in the diet, the effect of fructose exposure during pregnancy and lactation is of increasing relevance. Human studies have identified a clear effect of fructose consumption on maternal health, but little is known of the direct or indirect effects on offspring. Animal models have been utilized to evaluate this concept and an association between maternal fructose and offspring chronic disease, including hypertension and metabolic syndrome. This review will address the mechanisms of developmental programming by maternal fructose and potential options for intervention.
关键词：enfructose;metabolism;obesity;hypertension;metabolic syndrome;diabetes;uric acid;developmental origins hypothesis of adult disease (DOHaD)