文章基本信息

标题：Optimization of collimator angles in dual-arc volumetric modulated arc therapy planning for whole-brain radiotherapy with hippocampus and inner ear sparing
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作者：Wuji Sun ; Kunzhi Chen ; Yu Li 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-98530-7
语种：English
出版社：Springer Nature
摘要：To optimize the collimator angles in dual-arc volumetric modulated arc therapy (VMAT) plans for whole-brain radiotherapy with hippocampus and inner ear sparing (HIS-WBRT). Two sets of dual-arc VMAT plans were generated for 13 small-cell lung cancer patients: (1) The collimator angles of arcs 1 and 2 ( θ 1/ θ 2) were 350°/10°, 350°/30°, 350°/45°, 350°/60°, and 350°/80°, i.e., the intersection angle of θ 1 and θ 2 (Δ θ) increased. (2) θ 1/ θ 2 were 280°/10°, 300°/30°, 315°/45°, 330°/60°, and 350°/80°, i.e., Δ θ = 90°. The conformity index ( CI), homogeneity index ( HI), monitor units (MUs), and dosimetric parameters of organs-at-risk were analyzed. Quality assurance for Δ θ = 90° plans was performed. With Δ θ increasing towards 90°, a significant improvement was observed for most parameters. In 350°/80° plans compared with 350°/10° ones, CI and HI were improved by 1.1% and 25.2%, respectively; MUs were reduced by 16.2%; minimum, maximum, and mean doses ( D 100%, D max, and D mean, respectively) to the hippocampus were reduced by 5.5%, 6.3%, and 5.4%, respectively; D mean to the inner ear and eye were reduced by 0.7% and 5.1%, respectively. With Δ θ kept at 90°, the plan quality was not significantly affected by θ 1/ θ 2 combinations. The gamma-index passing rates in 280°/10° and 350°/80° plans were relatively lower compared with the other Δ θ = 90° plans. Δ θ showed a significant effect on dual-arc VMAT plans for HIS-WBRT. With Δ θ approaching 90°, the plan quality exhibited a nearly continuous improvement, whereas with Δ θ = 90°, the effect of θ 1/ θ 2 combination was insignificant.