文章基本信息

标题：Dialyzer surface area is a significant predictor of mortality in patients on hemodialysis: a 3-year nationwide cohort study
本地全文：下载
作者：Masanori Abe ; Ikuto Masakane ; Atsushi Wada 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-99834-4
语种：English
出版社：Springer Nature
摘要：A target Kt/V of > 1.4 and use of a high-flux dialyzer are recommended for patients on hemodialysis. However, there is little information on the relationship between the dialyzer surface area and mortality in these patients. In this nationwide cohort study, we aimed to clarify this relationship by analyzing data from the Japanese Society for Dialysis Therapy for 2010–2013. We enrolled 234,638 patients on hemodialysis who were divided according to quartile for dialyzer surface area into the S group (small, < 1.5 m 2), M group (medium, 1.5 m 2), L group (large, 1.6 to < 2.0 m 2), or XL group (extra-large, ≥ 2.0 m 2). We assessed the association of each group with 3-year mortality using Cox proportional hazards models and performed propensity score matching analysis. By the end of 2013, a total of 53,836 patients on dialysis (22.9%) had died. There was a significant decrease in mortality with larger dialyzer surface areas. The hazard ratio (95% confidence interval) was significantly higher in the S group (1.15 [1.12–1.19