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标题：Molecular imaging of myogenic stem/progenitor cells with [ ¹⁸F]-FHBG PET/CT system in SCID mice model of post-infarction heart
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作者：Weronika Wargocka-Matuszewska ; Katarzyna Fiedorowicz ; Anna Rugowska 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-98861-5
语种：English
出版社：Springer Nature
摘要：Preclinical and clinical studies have shown that stem cells can promote the regeneration of damaged tissues, but therapeutic protocols need better quality control to confirm the location and number of transplanted cells. This study describes in vivo imaging while assessing reporter gene expression by its binding to a radiolabelled molecule to the respective receptor expressed in target cells. Five mice underwent human skeletal muscle-derived stem/progenitor cell (huSkMDS/PC EF1-HSV-TK) intracardial transplantation after induction of myocardial infarction (MI). The metabolic parameters of control and post-infarction stem progenitor cell-implanted mice were monitored using 2-deoxy-18F-fluorodeoxyglucose ([ 18F