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标题：Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma
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作者：Nina Li ; Hoomann Mirzakhani ; Alexander Kiefer 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：10
页码：1-19
DOI：10.1016/j.isci.2021.103163
语种：English
出版社：Elsevier
摘要：SummaryRANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.Graphical abstractDisplay OmittedHighlights•RANTES is associated with allergic asthma and T cell-dependent clearance of infections•RANTES is upregulated in asthmatic airways reflecting ongoing airway cell activation•Rhinovirus inhibited and antiviral agonist induced RANTES in PBMCs from asthmatics•Experimental treatment with RANTES (rRANTES) in the airways reduced local eosinophilsBiological sciences; Immunology; Respiratory medicine