文章基本信息

标题：Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus
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作者：Kazuya Kawabata ; Epifanio Bagarinao ; Hirohisa Watanabe 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：10
页码：1-18
DOI：10.1016/j.isci.2021.103106
语种：English
出版社：Elsevier
摘要：SummaryThe thalamus is critical for the brain's integrative hub functions; however, the localization and characterization of the different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ratio (FCOR), we examined the thalamus' association with large-scale resting-state networks (RSNs) to elucidate its connector hub roles. Connections to the core-neurocognitive networks were localized in the anterior and medial parts, such as the anteroventral and mediodorsal nuclei areas. Regions functionally connected to the sensorimotor network were distinctively located around the lateral pulvinar nucleus but to a limited extent. Prominent connector hubs include the anteroventral, ventral lateral, and mediodorsal nuclei with functional connections to multiple RSNs. These findings suggest that the thalamus, with extensive connections to most of the RSNs, is well placed as a critical integrative functional hub and could play an important role for functional integration facilitating brain functions associated with primary processing and higher cognition.Graphical abstractDisplay OmittedHighlights•Multiple large-scale cortical networks converged in the thalamus•Neurocognitive associated hub existed in the anterior and medial region•Control-processing hub localized in the intermediate thalamus•Sensorimotor network was located around the lateral pulvinar nucleusSystems neuroscience; Sensory neuroscience; Cognitive neuroscience; Neural networks