文章基本信息

标题：A hierarchical processing unit for multi-component behavior in the avian brain
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作者：Noemi Rook ; John Michael Tuff ; Julian Packheiser 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：10
页码：1-19
DOI：10.1016/j.isci.2021.103195
语种：English
出版社：Elsevier
摘要：SummaryMulti-component behavior is a form of goal-directed behavior that depends on the ability to execute various responses in a precise temporal order. Even though this function is vital for any species, little is known about how non-mammalian species accomplish such behavior and what the underlying neural mechanisms are. We show that humans and a non-mammalian species (pigeons) perform equally well in multi-component behavior and provide a validated experimental approach useful for cross-species comparisons. Applying molecular imaging methods, we identified brain regions most important for the examined behavioral dynamics in pigeons. Especially activity in the nidopallium intermedium medialis pars laterale (NIML) was specific to multi-component behavior since only activity in NIML was predictive for behavioral efficiency. The data suggest that NIML is important for hierarchical processing during goal-directed behavior and shares functional characteristics with the human inferior frontal gyrus in multi-component behavior.Graphical abstractDisplay OmittedHighlights•Pigeons and humans perform equally well in the STOP-CHANGE paradigm•We identified relevant brain regions for the examined behavioral dynamics in pigeons•ZENK expression in NIML was predictive for behavioral efficiency•This study provides a validated experimental approach for cross-species comparisonsBiological sciences; Neuroscience; Behavioral neuroscience; Cognitive neuroscience