文章基本信息

标题：Green oxygen power plants in the brain rescue neuronal activity
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作者：Suzan Özugur ; Myra N. Chávez ; Rosario Sanchez-Gonzalez 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：10
页码：1-17
DOI：10.1016/j.isci.2021.103158
语种：English
出版社：Elsevier
摘要：SummaryNeuronal activity in the brain depends on mostly aerobic generation of energy equivalents and thus on a constant O2supply. Oxygenation of the vertebrate brain has been optimized during evolution by species-specific uptake and transport of O2that originally derives from the phototrophic activity of prokaryotic and eukaryotic organisms in the environment. Here, we employed a concept that exploits transcardial injection and vascular distribution of unicellular green algae or cyanobacteria in the brain ofXenopus laevistadpoles. Using oxygen measurements in the brain ventricle, we found that these microorganisms robustly produce sizable amounts of O2upon illumination. In a severe hypoxic environment, when neuronal activity has completely ceased, the photosynthetic O2reliably provoked a restart and rescue of neuronal activity. In the future, phototrophic microorganisms might provide a novel means to directly increase oxygen levels in the brain in a controlled manner under particular eco-physiological conditions or following pathological impairments.Graphical abstractDisplay OmittedHighlights•Transcardially injected microalgae accumulate in brain blood vessels ofXenopus•Upon illumination, green algae and cyanobacteria robustly produce O2in the brain•After hypoxic loss of brain function, photosynthetic oxygen rescues neural activityClassification Description: Animal physiology; Neuroscience; Microbiology; Biotechnology