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标题：NK-B cell cross talk induces CXCR5 expression on natural killer cells
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作者：Philippe Rascle ; Béatrice Jacquelin ; Caroline Petitdemange 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：10
页码：1-23
DOI：10.1016/j.isci.2021.103109
语种：English
出版社：Elsevier
摘要：SummaryB cell follicles (BCFs) in lymph nodes (LNs) are generally exempt of CD8+T and NK cells. African green monkeys (AGMs), a natural host of simian immunodeficiency virus (SIV), display NK cell-mediated viral control in BCF. NK cell migration into BCF in chronically SIVagm-infected AGM is associated with CXCR5+NK cells. We aimed to identify the mechanism leading to CXCR5 expression on NK cells. We show that CXCR5+NK cells in LN were induced following SIVagm infection. CXCR5+NK cells accumulated preferentially in BCF with proliferating B cells. Autologous NK-B cell co-cultures in transwell chambers induced CXCR5+NK cells. Transcriptome analysis of CXCR5+NK cells revealed expression ofbcl6andIL6R. IL-6 induced CXCR5 on AGM and human NK cells.IL6mRNA was detected in LN at higher levels during SIVagm than SIVmac infection and often produced by plasma cells. Our study reveals a mechanism of B cell-dependent NK cell regulation.Graphical abstractDisplay OmittedHighlights•IL-6 can induce CXCR5 on NK cells•CXCR5+NK cells expressed high levels ofbcl6andIL6R•More IL-6+plasmablast/plasma cells in lymph nodes in SIVagm than SIVmac infection•B cells participate in the regulation of NK cell migration into BCFImmunology; Virology