文章基本信息

标题：Real-time monitoring of deformed wing virus-infected bee foraging behavior following histone deacetylase inhibitor treatment
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作者：Cheng-Kang Tang ; Yu-Hsien Lin ; Joe-Air Jiang 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：10
页码：1-19
DOI：10.1016/j.isci.2021.103056
语种：English
出版社：Elsevier
摘要：SummaryImpairment in the learning/memory behavior of bees is responsible for the massive disappearance of bee populations and its consequent agricultural economic losses. Such impairment might be because of o both pesticide exposure and pathogen infection, with a key contributor deformed wing virus (DWV). The present study found that sodium butyrate (NaB) significantly increased survival and reversed the learning/memory impairment of DWV-infected bees. A next-generation sequencing analysis showed that NaB affected the expression of genes involved in glycolytic processes and memory formation, which were suppressed by DWV infection. In addition, we performed a large-scale movement tracking experiment by using a wireless sensor network-based automatic real-time monitoring system and confirmed that NaB could improve the homing ability of DWV-infected bees. In short, we demonstrated the mechanism of how epigenetic regulation can resume the memory function of honeybees and suggest strategies for applying NaB to reduce the incidence of colony losses.Graphical abstractDisplay OmittedHighlights•Sodium butyrate (NaB) reversed learning ability of bees infected by deformed wing virus•RNA-Seq showed NaB restored the expression of genes involved in glycolysis and memory•NaB improved the homing ability of deformed wing virus-infected beesEntomology; Ethology; Molecular biology; Omics