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标题：Bismuth (III) Chloride Catalyzed Multicomponent Synthesis of Substituted Hexahydroimidazo[1, 2-<i>a</i>]Pyridines
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作者：Noah T. Haskin ; Richard A. Guingrich ; Allison J. Schrader 等
期刊名称：Green and Sustainable Chemistry
印刷版ISSN：2160-6951
电子版ISSN：2160-696X
出版年度：2021
卷号：11
期号：3
页码：89-95
DOI：10.4236/gsc.2021.113008
语种：English
出版社：Scientific Research Publishing
摘要：The synthesis of nitrogen containing heterocycles is of particular interest in the pharmaceutical industry due to the range of biological activities exhibited by such compounds. Their synthesis using multicomponent reactions saves steps and minimizes waste generation. The bismuth (III) chloride multicomponent synthesis of a series of hexahydroimidazo[1, 2-a]pyridines is reported. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive. The reported method avoids chromatography and an aqueous waste stream to afford the products in a very mass efficient manner.
关键词：Bismuth Chloride;Green Chemistry;Heterocycles;Multicomponent Reactions