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标题：Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico
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作者：Pilar E. Núñez Ortega ; María E. Meneses ; Iván Delgado-Enciso 等
期刊名称：Journal of Physiological Anthropology
印刷版ISSN：1880-6791
电子版ISSN：1880-6805
出版年度：2021
卷号：40
期号：1
页码：1-10
DOI：10.1186/s40101-021-00259-9
语种：English
出版社：BMC
摘要：Abstract Background Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas. Methods In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components. Results The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3–5.3; p = 0.007). Conclusions Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.