文章基本信息

标题：P16 ^INK4A expression might be associated with a favorable prognosis for cervical adenocarcinoma via dysregulation of the RB pathway
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作者：Masako Ishikawa ; Kentaro Nakayama ; Kohei Nakamura 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-97703-8
语种：English
出版社：Springer Nature
摘要：Previous studies have largely failed to clarify the relationship between p16 INK4A status and cervical adenocarcinoma prognosis. The current study aimed to examine the clinical and pathological significance of p16 INK4A expression in several cervical adenocarcinoma subtypes. Eighty-two samples collected from patients with cervical adenocarcinoma were formalin fixed and paraffin embedded. Next, p16 INK4A levels were analyzed with immunohistochemistry. Additionally, the relationship between p16 INK4A expression and clinicopathological factors as well as prognosis was evaluated. The expression of p16 INK4A was mostly detected in all usual cervical adenocarcinoma subtypes. In the gastric type, only a few cases were positive for p16 INK4A expression. Results of the Kaplan–Meier analysis indicated that the positive p16 INK4A expression in tumor cells was significantly associated with favorable progression-free survival and overall survival in patients with cervical adenocarcinoma ( p = 0.018 and p = 0.047, respectively, log-rank test). Our findings suggest that the status of p16 INK4A expression may influence prognosis. Thus, p16 INK4A expression could be used as a biomarker for improving the prognosis of patients with cervical adenocarcinoma.