文章基本信息

标题：Antimicrobial peptides: mechanism of action, activity and clinical potential
本地全文：下载
作者：Qi-Yu Zhang ; Zhi-Bin Yan ; Yue-Ming Meng 等
期刊名称：Military Medical Research
印刷版ISSN：2054-9369
出版年度：2021
卷号：8
DOI：10.1186/s40779-021-00343-2
语种：English
出版社：BioMed Central
摘要：The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics. Supplementary Information The online version contains supplementary material available at 10.1186/s40779-021-00343-2.
关键词：Antimicrobial peptides; Antimicrobial resistance; Mechanism of action; Biological activity; Clinical application