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标题：Sugar- and Artificially Sweetened Beverages Consumption Linked to Type 2 Diabetes, Cardiovascular Diseases, and All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
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作者：Yantong Meng ; Siqi Li ; Jabir Khan 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：8
DOI：10.3390/nu13082636
语种：English
出版社：MDPI Publishing
摘要：Although studies have examined the association between habitual consumption of sugar- (SSBs) and artificially sweetened beverages (ASBs) and health outcomes, the results are inconclusive. Here, we conducted a dose-response meta-analysis of prospective cohort studies in order to summarize the relationship between SSBs and ASBs consumption and risk of type 2 diabetes (T2D), cardiovascular diseases (CVDs), and all-cause mortality. All relevant articles were systematically searched in PubMed, Embase, and Ovid databases until 20 June 2020. Thirty-four studies met the inclusion criteria and were eligible for analysis. Summary relative risks (RRs) and 95% confidence intervals (95% CI) were estimated using random effects or fixed-effects model for highest versus lowest intake categories, as well as for linear and non-linear relationships. With each additional SSB and ASB serving per day, the risk increased by 27% (RR: 1.27, 95%CI: 1.15–1.41, I 2 = 80.8%) and 13% (95%CI: 1.03–1.25, I 2 = 78.7%) for T2D, 9% (RR: 1.09, 95%CI: 1.07–1.12, I 2 = 42.7%) and 8% (RR: 1.08, 95%CI: 1.04–1.11, I 2 = 45.5%) for CVDs, and 10% (RR: 1.10, 95%CI: 0.97–1.26, I 2 = 86.3%) and 7% (RR: 1.07, 95%CI: 0.91–1.25, I 2 = 76.9%) for all-cause mortality. Linear relationships were found for SSBs with T2D and CVDs. Non-linear relationships were found for ASBs with T2D, CVDs, and all-cause mortality and for SSBs with all-cause mortality. The findings from the current meta-analysis indicate that increased consumption of SSBs and ASBs is associated with the risk of T2D, CVDs, and all-cause mortality.
关键词：ensugar-sweetened beverages;artificially sweetened beverages;type 2 diabetes;cardiovascular diseases;all-cause mortality