文章基本信息

标题：Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies
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作者：Bianca Papotti ; Joan Carles Escolà-Gil ; Josep Julve 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：8
DOI：10.3390/nu13082643
语种：English
出版社：MDPI Publishing
摘要：Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.
关键词：enreverse cholesterol transport;HDL;fatty acids;sterols;rodents