文章基本信息

标题：Bioelectromagnetic Platform for Cell, Tissue, and In Vivo Stimulation
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作者：Ryan C. Ashbaugh ; Lalita Udpa ; Ron R. Israeli 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2021
卷号：11
期号：8
DOI：10.3390/bios11080248
语种：English
出版社：MDPI Publishing
摘要：Magnetogenetics is a new field that utilizes electromagnetic fields to remotely control cellular activity. In addition to the development of the biological genetic tools, this approach requires designing hardware with a specific set of demands for the electromagnets used to provide the desired stimulation for electrophysiology and imaging experiments. Here, we present a universal stimulus delivery system comprising four magnet designs compatible with electrophysiology, fluorescence and luminescence imaging, microscopy, and freely behaving animal experiments. The overall system includes a low-cost stimulation controller that enables rapid switching between active and sham stimulation trials as well as precise control of stimulation delivery thereby enabling repeatable and reproducible measurements.
关键词：enhigh-throughput magnetogenetics;in vivo stimulation;head-fixed experiments;neuromodulation;minimally-invasive brain stimulation