文章基本信息

标题：Multimodal Early Alzheimer’s Detection, a Genetic Algorithm Approach with Support Vector Machines
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作者：Ana G. Sánchez-Reyna ; José M. Celaya-Padilla ; Carlos E. Galván-Tejada 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2021
卷号：9
期号：8
DOI：10.3390/healthcare9080971
语种：English
出版社：MDPI Publishing
摘要：Alzheimer’s disease (AD) is a neurodegenerative disease that mainly affects older adults. Currently, AD is associated with certain hypometabolic biomarkers, beta-amyloid peptides, hyperphosphorylated tau protein, and changes in brain morphology. Accurate diagnosis of AD, as well as mild cognitive impairment (MCI) (prodromal stage of AD), is essential for early care of the disease. As a result, machine learning techniques have been used in recent years for the diagnosis of AD. In this research, we propose a novel methodology to generate a multivariate model that combines different types of features for the detection of AD. In order to obtain a robust biomarker, ADNI baseline data, clinical and neuropsychological assessments (1024 features) of 106 patients were used. The data were normalized, and a genetic algorithm was implemented for the selection of the most significant features. Subsequently, for the development and validation of the multivariate classification model, a support vector machine model was created, and a five-fold cross-validation with an AUC of 87.63% was used to measure model performance. Lastly, an independent blind test of our final model, using 20 patients not considered during the model construction, yielded an AUC of 100%.
关键词：enAlzheimer’s disease;support vector machine;genetic algorithm