文章基本信息

标题：Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells
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作者：Zhi-Fang Sun ; Yong Chang ; Ning Xia 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2021
卷号：11
期号：8
DOI：10.3390/bios11080281
语种：English
出版社：MDPI Publishing
摘要：The accurate analysis of circulating tumor cells (CTCs) holds great promise in early diagnosis and prognosis of cancers. However, the extremely low abundance of CTCs in peripheral blood samples limits the practical utility of the traditional methods for CTCs detection. Thus, novel and powerful strategies have been proposed for sensitive detection of CTCs. In particular, nanomaterials with exceptional physical and chemical properties have been used to fabricate cytosensors for amplifying the signal and enhancing the sensitivity. In this review, we summarize the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, including fluorescence, colorimetry, surface-enhanced Raman scattering, chemiluminescence, electrochemistry, electrochemiluminescence, photoelectrochemistry and so on.
关键词：encirculating tumor cells;cancer biomarkers;electrochemical biosensors;optical biosensors;nanomaterials