文章基本信息

标题：Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology
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作者：Anja Werner ; Simon Schäfer ; Olga Zaytseva 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：9
页码：1-28
DOI：10.1016/j.isci.2021.103076
语种：English
出版社：Elsevier
摘要：SummarySystemic lupus erythematosus (SLE) is characterized by a loss of self-tolerance, systemic inflammation, and multi-organ damage. While a variety of therapeutic interventions are available, it has become clear that an early diagnosis and treatment may be key to achieve long lasting therapeutic responses and to limit irreversible organ damage. Loss of humoral tolerance including the appearance of self-reactive antibodies can be detected years before the actual onset of the clinical autoimmune disease, representing a potential early point of intervention. Not much is known, however, about how and to what extent this pre-phase of disease impacts the onset and development of subsequent autoimmunity. By targeting the B cell compartment in the pre-disease phase of a spontaneous mouse model of SLE we now show, that resetting the humoral immune system during the clinically unapparent phase of the disease globally alters immune homeostasis delaying the downstream development of systemic autoimmunity.Graphical abstractDisplay OmittedHighlights•The clinically unapparent pre-phase of SLE impacts clinical disease•Autoreactive IgM antibodies represent a biomarker for early therapeutic intervention•Pre-phase B cells orchestrate clinical disease•Depleting pre-phase B cells diminishes disease pathologyBiological sciences; Immune system disorder; Immune response.