摘要:Climate change is impacting human health. The 2020 report of the LancetCountdown on health and climate change 1 estimates a 53∙7% increase in heat-related mortality in people older than 65 years during the past 2 decades. Nowadays, most of the record-breaking temperature extremes are directly attributable to climate change, 2 and these events are continuously redefining the range of observed climatological temperatures to which populations are exposed. These previously unobserved temperatures pose an additional threat to human health, as exemplified by the recordbreaking heatwave in the summer of 2003, which caused a mortality excess of more than 70 000 premature deaths in Europe. 3 In this Comment, we show for the first time the contribution of previously unobserved extreme heat to the trends and seasonality changes of temperature-attributable mortality (TAM) projections in 147 contiguous regions in 16 European countries (Austria [n=9 regions], Belgium [n=11], Croatia [n=2], Czech Republic [n=8], Denmark [n=1], France [n=22], Germany [n=16], Italy [n=21], Luxembourg [n=1], the Netherlands [n=1], Poland [n=16], Portugal [n=5], Slovenia [n=1], Spain [n=16], Switzerland [n=7], and the UK [n=10 regions in England and Wales only]).