文章基本信息

标题：介護施設従業員における主観的健康感と炎症マーカーの関連
本地全文：下载
作者：井上由貴子 ; 中田光紀 ; 栗岡住子等
期刊名称：産業衛生学雑誌
印刷版ISSN：1341-0725
电子版ISSN：1349-533X
出版年度：2021
卷号：63
期号：4
页码：117-128
DOI：10.1539/sangyoeisei.2020-020-B
语种：Japanese
出版社：Japan Society for Occupational Health
摘要：目的：主観的健康感は健康状態を自己評価する指標であり，免疫機能と関連することが報告されているが，種類の異なる3つの健康感指標（全般的，過去比較および他者比較）と炎症マーカーの関連ならびに年齢別のそれらの相対的な関連の強さについてはまだ十分に理解できていない.本研究は介護施設従業員を対象に，異なる健康感指標と炎症マーカーとの関連を検討した.対象と方法：介護施設で働く21歳～68歳（平均40.9歳）の職員120名（女性90名，男性30名）を対象に，健康診断に併せて血中炎症マーカー（インターフェロン-γ，インターロイキン［IL］-4，IL-6，腫瘍壊死因子［Tumor Necrosis Factor; TNF］-α，白血球数）を測定すると同時に質問紙により主観的健康感を尋ねた.重回帰分析にて共変量を調整し，40歳未満および40歳以上で層別化を行ったうえで，炎症マーカーと主観的健康感の関連を解析した.結果：全ての潜在的共変量を調整したモデルにおいて，40歳以上の高齢層では，全般的健康感の悪化はIL-6の増加と有意に関連し，40歳未満の若年層では他者比較健康感の悪化はTNF-αの増加と有意に関連した.他者比較健康感の悪化は参加者全体においてもIL-6の増加と有意に関連した.過去比較健康感は炎症マーカーと明確な関連を示さなかった.考察と結論：本研究の結果から，主観的健康感指標の種類が異なれば炎症マーカーとの関連も異なること，特にこれらの関連は，若年層と高齢層に分けて行うことでより明確になることが明らかとなった.これは，健康感指標の相違のみならず年齢も主観的健康感と炎症マーカーの関連を修飾することを示唆する.
其他摘要：Objectives: Although self-rated health (SRH), the self-evaluation of one’s own health status, has been reported to be associated with the immune status, the relationship between three different SRH measures (global, self-comparative, and age-comparative) with inflammatory markers as well as the relative strength of these associations by age are not well understood. The current study investigated the associations between SRH measures and inflammatory markers among nursing home employees. Methods: A sample of 120 Japanese employees at a nursing home (90 women and 30 men), aged 21–68 years (mean, 40.9 years), underwent a blood test for the measurement of inflammatory markers (interferon-γ, interleukin [IL]-4, IL-6, and tumor necrosis factor [TNF]-α, white blood cell count) and SRH during the annual health checkup. Multiple regression analysis adjusted for covariates was performed to analyze the relationship between inflammatory markers and SRH measures stratified by age, that is, aged < 40 years (younger age group) and 40 years and over (older age group). Results: Among the participants aged 40 years and over, poor global SRH was significantly associated with an increase in IL-6, while poor age-comparative SRH was significantly associated with an increase in TNF-α among participants aged < 40 years in the fully adjusted model controlling for potential confounders. Age-comparative SRH was also significantly associated with an increase in IL-6 among all participants. Self-comparative SRH was not significantly associated with inflammatory markers. Conclusions: Our results suggest that three SRH measures are not equivalently associated with inflammatory markers, especially when the analyses were performed separately for the younger and older populations. This implies that not only differences in forms of SRH but also in age modify the relationship between SRH and inflammatory markers.
关键词：Self-rated health;Perceived health;Inflammatory markers;Cytokine;Immune system;Nursing home employee