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标题：Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19
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作者：Sara Velazquez ; Rodrigo Madurga ; José María Castellano 等
期刊名称：BMC Emergency Medicine
印刷版ISSN：1471-227X
电子版ISSN：1471-227X
出版年度：2021
卷号：21
DOI：10.1186/s12873-021-00480-w
语种：English
出版社：BioMed Central
摘要：Background The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio (NPR), could help identify patients who at risk of admission at Intensive Care Units. Methods A retrospective observational study was performed at HM Hospitales including electronic health records from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two groups, admitted at ICU or not. Results Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found significant differences in NLR (6.9 [4–11.7
关键词：COVID-19; Hemogram; Hemogram-derived ratio; Neutrophil-to-platelet ratio; Neutrophil-to-lymphocyte ratio; ICU admission