文章基本信息

标题：Preparation of Carbamazepine-Nicotinamide Cocrystal
本地全文：下载
作者：Huirong Ying ; Jinna Zhang ; Chengjun Jiang 等
期刊名称：Open Access Library Journal
印刷版ISSN：2333-9705
电子版ISSN：2333-9721
出版年度：2021
卷号：8
期号：7
页码：1-8
DOI：10.4236/oalib.1107605
语种：English
出版社：Scientific Research Pub
摘要：The focus of this investigation was to prepare the cocrystal of carbamazepine (CBZ) using nicotinamide as a coformer and to compare its different preparation methods. The cocrystal was prepared by grinding, solvent-Assisted grinding and ultrasound-assisted cocrystallization methods. They were characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and morphology by electron microscopy. In conclusion, ultrasound can be applied as a process intensification parameter along with cooling or slurry cocrystallization to produce pure cocrystals under conditions that might result in crystal mixtures in conventional processes.
关键词：CarbamazepineNicotinamideCocrystalUltrasound