摘要:Minimum inhibitory concentrations of lactic acid bacteria and other antagonist microorganisms isolated from natural sources of Kaliningrad region (soil, water bodies, plant objects) were determined. It was shown that the minimum inhibitory concentration ofPediococcus pentosaceusmetabolites againstEscherichia coliis 1.5·107 CFU/ml; Pseudomonas chlororaphismetaboliteshave no inhibitory effect against the test strain ofEscherichia coli under study. It was found thatPediococcus damnosusmetabolites adversely affect the growth ofEscherichia coli, but at a concentration of 1.5·107 CFU/ml after 6-24 hours of cultivation. For metabolites isolated byLactobacillus casei, the characteristic minimum inhibitory concentration with respect to the studiedEscherichia colistrain is 1.5-107 CFU/ml, and for metabolites isolated byLactobacillus fermentum, the minimum inhibitory concentration with respect to the studiedEscherichia colistrain is 1.5·105 CFU/ml. At a concentration ofBacteroides hypermegas (Megamonas hypermegale) metabolites equal to 1.5·106 CFU/ml, an optical density lower than that of the control is observed. The minimum concentration ofPseudomonas syringaemetabolites inhibitingEscherichia coliculture growth is 1.5-107 CFU/ml. For the metabolitesAcetobacter acetiandPsychrobacter urativorans, the concentration of 1.5·107 CFU/ml is the lowest to inhibit the growth ofEscherichia coli.