摘要:The article presents the results of studies to identify the role of endogenous intoxication in the pathogenetic mechanisms of heat stress in cows in a comparative aspect between healthy animals and animals with hepatopathology. The obtained data indicate that in summer period in a farm located on the flat territory of the Krasnodar region the cattle are influenced by the heat stress. The relationship between the state of moderate heat stress in dairy cattle and the dynamics of a number of indicators characterizing the syndrome of endogenous intoxication of their body was revealed. The increase in the concentration of medium mass molecules (MMM) in healthy livestock was almost two times lower than in animals with fatty hepatosis. The obtained results can serve as a rationale for the development of an effective strategy for pharmacological correction of heat stress in cattle.