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标题：Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
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作者：Hyo Young Jung ; Dae Young Yoo ; Young Kwang Jo 等
期刊名称：Laboratory Animal Research
印刷版ISSN：1738-6055
电子版ISSN：2233-7660
出版年度：2016
卷号：32
期号：2
页码：128-132
DOI：10.5625/lar.2016.32.2.128
语种：English
出版社：BioMed Central Ltd.
摘要：Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis. In the present study, we investigated the expression of estrogen and progesterone receptors in the normal and cryptorchid testis of a dog. Elective orchidectomy was performed on the dog’s abdominal right testis (undescended, cryptorchid) and scrotal left testis (descended, normal). In the normal testis, estrogen receptor a immunoreactivity was detected in Leydig cells alone, while estrogen receptor a immunoreactivity in the cryptorchid testis was significantly prominent in the Sertoli cells as well. In addition, progesterone receptor immunoreactivity in the control testis was detected in the spermatids, but was not detected in the cryptorchid testis. This result suggests that unilateral cryptorchidism causes increases of estrogen receptor a expression in Sertoli cells.
关键词：Dog;estrogen receptor ;progesterone receptor;Sertoli cells;unilateral cryptorchidism