文章基本信息

标题：Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice
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作者：Seyed Soheil Saeedi Saravi ; Nicole R. Bonetti ; Benoit Pugin 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：8
页码：1-21
DOI：10.1016/j.isci.2021.102897
语种：English
出版社：Elsevier
摘要：SummaryAging is a major risk factor for cardiovascular diseases, including thrombotic events. The gut microbiota has been implicated in the development of thrombotic risk. Plant-derived omega-3 fatty acid ɑ-linolenic acid (ALA) confers beneficial anti-platelet and anti-inflammatory effects. Hence, antithrombotic activity elicited by ALA may be partly dependent on its interaction with gut microbiota during aging. Here, we demonstrate that lifelong dietary ALA decreases platelet hyperresponsiveness and thrombus formation in aged mice. These phenotypic changes can be partly attributed to alteration of microbial composition and reduction of its metabolite trimethylamine N-oxide and inflammatory mediators including TNF-α, as well as the upregulated production of short-chain fatty acid acetate. ALA-rich diet also dampens secretion of increased procoagulant factors, tissue factor and plasminogen activator inhibitor-1, in aged mice. Our results suggest long-term ALA supplementation as an attractive, accessible, and well-tolerated nutritional strategy against age-associated platelet hyperreactivity and thrombotic potential.Graphical abstractDisplay OmittedHighlights•Gut microbiota-derived TMAO and SCFAs associate with thrombotic potential in aging•Lifelong dietary ALA suppresses thrombus formation in aged mice•ALA-rich diet regulates aged gut microbiota and its metabolites TMAO and acetate•ALA-rich diet dampens inflammatory state in aged miceHematology; Nutrition; Microbiome