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标题：Structural characterization of the mitochondrial Ca 2+ uniporter provides insights into Ca 2+ uptake and regulation
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作者：Wenping Wu ; Jimin Zheng ; Zongchao Jia 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：8
页码：1-18
DOI：10.1016/j.isci.2021.102895
语种：English
出版社：Elsevier
摘要：SummaryThe mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory subunits MCUb, EMRE, MICU1, and MICU2, have been identified in recent years. Previously, extensive studies revealed various aspects of uniporter activities and proposed multiple regulatory models of mitochondrial Ca2+uptake. Recently, the individual auxiliary components of the uniporter and its holocomplex have been structurally characterized, providing the first insight into the component structures and their spatial relationship within the context of the uniporter. Here, we review recent uniporter structural studies in an attempt to establish an architectural framework, elucidating the mechanism that governs mitochondrial Ca2+uptake and regulation, and to address some apparent controversies. This information could facilitate further characterization of mitochondrial Ca2+permeation and a better understanding of uniporter-related disease conditions.Graphical abstractDisplay OmittedHighlights•The uniporter contains multiple subunits regulating various cellular processes•Significant structural progresses have been made for the holo-complex of uniporter•The holo-complex structures have inspired to propose several regulatory modelsIon; Molecular biology; Membranes;