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标题：Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19
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作者：Yolande Ketchanji Mougang ; Lorena Di Zazzo ; Marilena Minieri 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：8
页码：1-17
DOI：10.1016/j.isci.2021.102851
语种：English
出版社：Elsevier
摘要：SummaryVolatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in more than 100 different VOCs, the pattern of abundances of 17 compounds identifies COVID-19 from non-COVID with an accuracy of 89% (sensitivity 94% and specificity 83%). GC/MS analysis was complemented by an array of gas sensors whose data achieved an accuracy of 89% (sensitivity 94% and specificity 80%).Graphical abstractDisplay OmittedHighlights•Volatile compounds released from human blood serum were analyzed•Blood serum of COVID-19 patients is identified by a pool of 17 volatile compounds•An array of gas sensors detects COVID-19 from serum volatile compounds analysisHealth sciences; Diagnostics; Biotechnology; Medical biotechnology