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标题：The Hippo pathway uses different machinery to control cell fate and organ size
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作者：Jonathan M. Pojer ; Samuel A. Manning ; Benjamin Kroeger 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：8
页码：1-18
DOI：10.1016/j.isci.2021.102830
语种：English
出版社：Elsevier
摘要：SummaryThe Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in theDrosophilaeye, where Hippo specifies whether cells sense blue or green light. We show that only a subset of proteins that control organ growth via the Hippo pathway also regulate R8 cell fate choice, including the STRIPAK complex, Tao, Pez, and 14-3-3 proteins. Furthermore, key Hippo pathway proteins were primarily cytoplasmic in R8 cells rather than localized to specific membrane domains, as in cells of growing epithelial organs. Additionally, Warts was the only Hippo pathway protein to be differentially expressed between R8 subtypes, while central Hippo pathway proteins were expressed at dramatically lower levels in adult and pupal eyes than in growing larval eyes. Therefore, we reveal several important differences in Hippo signaling in the contexts of organ growth and cell fate.Graphical abstractDisplay OmittedHighlights•A subset of Hippo pathway proteins control the fate of R8 photoreceptor neurons•Hippo pathway proteins are mostly cytoplasmic, not junctional, in R8 cells•Hippo pathway proteins are expressed higher in the growth phase of eye developmentDevelopmental biology; Entomology; Genetics; Molecular biology; Molecular genetics