文章基本信息

标题：Overlapping Community Detection on a Graph of Chemicals, Diseases and Genes for Drug Repositioning and Adverse Reactions Prediction
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作者：María Elena García-Ochagavía ; Yudivián Almeida-Cruz ; Suilán Estévez-Velarde 等
期刊名称：Revista Internacional de Gestión del Conocimiento y la Tecnología (GECONTEC)
印刷版ISSN：2255-5684
出版年度：2020
卷号：7
期号：2
页码：80-96
语种：English
出版社：Revista Internacional de Gestión del Conocimiento y la Tecnología (GECONTEC)
摘要：Developing a drug from scratch is a very long and expensive process that has a small probability of success. For this reason, pharmaceutical companies are devoting their efforts to find drugs that could be repositioned. When using a drug to treat a disease is necessary to consider what adverse reactions it may cause, this is why the prediction of adverse reactions is highly related to drug repositioning. We propose the detection of overlapping communities over a biological network of chemicals, diseases and genes in order to find drug-disease pairs that could be used as basis for later drug repositioning and adverse reactions prediction analysis. Of the evaluated overlapping community detection algorithms, OSLOM got the best results, producing 724 communities from which was possible to extract 215944 drug-disease pairs not present in the analyzed graph. We illustrate the usefulness of this set through examples of associations between pairs found in the scientific literature.