文章基本信息

标题：GIP_HUMAN[22–51] is a new proatherogenic peptide identified by native plasma peptidomics
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作者：Tsuguto Masaki ; Yoshio Kodera ; Michishige Terasaki 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-93862-w
语种：English
出版社：Springer Nature
摘要：We recently established a new plasma peptidomic technique and comprehensively identified a large number of low-molecular weight and low-abundance native peptides using a single drop of human plasma. To discover a novel polypeptide that potently modulates the cardiovascular system, we performed a bioinformatics analysis of the large-scale identification results, sequentially synthesized the selected peptide sequences, tested their biological activities, and identified a 30-amino-acid proatherogenic peptide, GIP_HUMAN[22–51