文章基本信息

标题：Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
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作者：Liuying Hu ; Yumiko Hayashi ; Hiroyasu Kidoya 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-93619-5
语种：English
出版社：Springer Nature
摘要：The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing vascular maturation. Here, we found that MC38 and LLC tumor growth were greater in the absence of Apelin than in wild-type (WT) mice, suggesting that Apelin acts as a tumor suppressor. Consistent with this, treating WT mice with [Pyr 1