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标题：In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol
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作者：Qiankun Shi ; Xinya Wang ; Xudong Tang 等
期刊名称：Food Science & Nutrition
电子版ISSN：2048-7177
出版年度：2021
卷号：9
期号：7
页码：3530-3537
DOI：10.1002/fsn3.2302
语种：English
出版社：John Wiley & Sons, Ltd.
摘要：Resveratrol (RES) loaded Zein‐SHA (low‐molecular‐weight sodium hyaluronate) nanoparticles with average diameter of about 152.13 nm and polydispersity index (PDI) of 0.122, which can be used to encapsulate, protect and deliver resveratrol. By measuring ABTS free radical scavenging ability and iron (III) reducing power, it was determined that encapsulated resveratrol has higher in vitro antioxidant activity than free resveratrol. When tested with murine breast cancer cells 4T1, the encapsulated resveratrol also showed higher antiproliferative activity than free resveratrol, with IC50 values of 14.73 and 17.84 μg/ml, respectively. The colloidal form of resveratrol developed in this research may be particularly suitable for functional foods and beverages, as well as dietary supplements and pharmaceutical products.
关键词：anticancer activity;antioxidant activity;nanoparticles;resveratrol;SHA;zein