文章基本信息

标题：Development of Magnetic Particle Distribution Imaging Using Magnetic Field Reconstruction for Biopsy of the Sentinel Lymph Node
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作者：Akari Inagaki ; Tomoko Suzuki ; Yuki Mima 等
期刊名称：Maine Policy Review
印刷版ISSN：2312-7481
出版年度：2021
卷号：7
期号：6
页码：85
DOI：10.3390/magnetochemistry7060085
语种：English
出版社：The University of Maine
摘要：The sentinel lymph node is the first lymph-node-draining cancer metastasis. The identification of the sentinel lymph node using magnetic particles and a magnetic sensor has attracted attention in recent years, as this method is less invasive than the conventional method of radiotracer injection. However, the development of a two-dimensional measurement method for sentinel lymph nodes using magnetic nanoparticles remains an issue. In the present study, a method and apparatus for the two-dimensional imaging of magnetic particle distribution were developed to detect a lymph node with magnetic particles concentrated within lymphoid tissues. The method comprises the reconstruction of the magnetic field measured with a high-sensitivity magnetic sensor and with a magnetic detection ability of 2 nT/√Hz at 100 Hz (5 nT/√Hz at 1 Hz). The proposed system measures the two-dimensional magnetic field distribution in an area of up to 25 × 25 mm<sup>2</sup> using a coil generating a 0.77 mT external magnetic field applied to the measurement target. The improved spatial resolution of the images makes it possible to use two-dimensional imaging for diagnostics of breast cancer metastases.