文章基本信息

标题：Intergenerational transmission of the patterns of functional and structural brain networks
本地全文：下载
作者：Yu Takagi ; Naohiro Okada ; Shuntaro Ando 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：7
页码：1-21
DOI：10.1016/j.isci.2021.102708
语种：English
出版社：Elsevier
摘要：SummaryThere is clear evidence of intergenerational transmission of life values, cognitive traits, psychiatric disorders, and even aspects of daily decision making. To investigate biological substrates of this phenomenon, the brain has received increasing attention as a measurable biomarker and potential target for intervention. However, no previous study has quantitatively and comprehensively investigated the effects of intergenerational transmission on functional and structural brain networks. Here, by employing an unusually large cohort dataset (N = 84 parent-child dyads; 45 sons, 39 daughters, 81 mothers, and 3 fathers), we show that patterns of functional and structural brain networks are preserved over a generation. We also demonstrate that several demographic factors and behavioral/physiological phenotypes have a relationship with brain similarity. Collectively, our results provide a comprehensive picture of neurobiological substrates of intergenerational transmission and demonstrate the usability of our dataset for investigating the neurobiological substrates of intergenerational transmission.Graphical abstractDisplay OmittedHighlights•Functional and structural brain networks can reliably identify parent-child dyads•Functional and structural brain networks have complementary roles•Behavioral and physiological measures have relationships with brain similarityBehavioral neuroscience; Systems neuroscience; Techniques in neuroscience;