文章基本信息

标题：Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression
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作者：Angelina Volkova ; Kelly Ruggles ; Anjelique Schulfer 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2021
卷号：24
期号：7
页码：1-18
DOI：10.1016/j.isci.2021.102797
语种：English
出版社：Elsevier
摘要：SummaryWe have established experimental systems to assess the effects of early-life exposures to antibiotics on the intestinal microbiota and gene expression in the brain. This model system is highly relevant to human exposure and may be developed into a preclinical model of neurodevelopmental disorders in which the gut–brain axis is perturbed, leading to organizational effects that permanently alter the structure and function of the brain. Exposing newborn mice to low-dose penicillin led to substantial changes in intestinal microbiota population structure and composition. Transcriptomic alterations implicate pathways perturbed in neurodevelopmental and neuropsychiatric disorders. There also were substantial effects on frontal cortex and amygdala gene expression by bioinformatic interrogation, affecting multiple pathways underlying neurodevelopment. Informatic analyses established linkages between specific intestinal microbial populations and the early-life expression of particular affected genes. These studies provide translational models to explore intestinal microbiome roles in the normal and abnormal maturation of the vulnerable central nervous system.Graphical abstractDisplay OmittedHighlights•Low-dose antibiotic exposure perturbs the infant gut mouse microbiome to PND10•Frontal cortex and amygdala gene expression were substantially affected•Multiple pathways underlying neurodevelopment were affected•Specific gut microbial populations were linked with expression of particular genesDevelopmental neuroscience; Microbiome