文章基本信息

标题：Regulating gene expression to achieve temporal precision ⁎ ⁎
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作者：Khem Raj Ghusinga ; Abhyudai Singh
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2021
卷号：54
期号：9
页码：502-506
DOI：10.1016/j.ifacol.2021.06.108
语种：English
出版社：Elsevier
摘要：AbstractCellular response to a stimulus is often triggered by accumulation of an appropriate gene product up to a critical threshold. How cells regulate gene expression to achieve precision in timing of such responses is a question of interest. Earlier work has shown that for a stable gene product, a constant rate of accumulation provides minimum noise in the time of response, provided that initial gene product distribution is degenerate. Here, we show that this strategy is no longer optimal if the initial gene product level is drawn from a non-degenerate distribution. We also discuss biological relevance of this finding.