文章基本信息

标题：Global and local synaptic regulation determines stability of homeostatic plasticity ⁎ ⁎
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作者：Saeed Aljaberi ; Adriano Bellotti ; Timothy O’Leary 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2021
卷号：54
期号：9
页码：496-501
DOI：10.1016/j.ifacol.2021.06.107
语种：English
出版社：Elsevier
摘要：AbstractNeurons regulate the distribution of signaling components across an extended tree-like cellular structure using both local and global feedback control. This is hypothesized to allow homeostatic control of the electrical activity of a neuron and at the same time enable normalization of distribution of inputs received from other cells. The performance and robustness of these mechanisms are poorly understood, and are subject to nonlinearities, making their analysis difficult. Firstly, we formally show thatglobalhomeostasis of electrical activity andlocalactivity-dependent degradation can coexist under sufficient timescale separation. The interplay of the two feedback mechanisms is also analyzed through simulations, which reveal a bidirectional effect (stabilizing and destabilizing) of activity-dependent degradation on the overall neuron performance.
关键词：Keywordsdendritic traffickinghomeostasisstability