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标题：Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice
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作者：Ki Mo Kim ; Joo Young Lee ; Byeong Hwa Jeon 等
期刊名称：Nutrition Research and Practice
印刷版ISSN：1976-1457
出版年度：2021
卷号：15
期号：3
页码：319-328
DOI：10.4162/nrp.2021.15.3.319
语种：English
出版社：KoreaMed Synapse
摘要：BACKGROUND/OBJECTIVES Curcuma zedoaria R. ( Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a C. zedoaria extract (CzE) affected atherosclerosis in vivo. MATERIALS/METHODS Apolipoprotein E-deficient (ApoE −/−) mice (n = 32) were fed a normal diet (ND), a high-cholesterol diet (HCD), an HCD containing CzE (100 mg/kg/day), or an HCD containing simvastatin (10 mg/kg/day) for 12 weeks. The anti-atherosclerotic effects were evaluated by observing changes in fatty streak lesions, immunohistochemical analysis, ex vivo fluorescence imaging, lipid profiles, and western blot analysis. RESULTS The CzE-fed group showed a 41.6% reduction of atherosclerosis. Furthermore, CzE significantly reduced the levels of serum triglyceride, high-density lipoprotein, the chemokine (C-X3-C-motif) ligand 1, the adhesion molecules vascular cell adhesion molecule-1, intracellular adhesion molecule-1, and E-selectin; down-regulation of tumor necrosis factor-α, interleukin-6, high mobility group box-1, and cathepsin levels in the aortic sinuses and aortas of ApoE −/− mice were also observed. CONCLUSIONS The results suggest that the inclusion of a water extract of C. zedoaria in a HCD is closely correlated with reducing the risk of vascular inflammatory diseases in an ApoE mouse model.
关键词：enCurcuma zedoaria;atherosclerosis;ApoE knockout mice;VCAM-1;chemokine CX3CL1